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However, you can be more likely to sunburn Learn about drug interactions between benazepril oral and sulfamethoxazole-trimethoprim oral and use the RxList drug interaction checker to check drug combinations. Com/community/ask/does Antibiotics that have been shown to interact with birth control pills include rifampin (Rifadin®), and to a lesser extent, penicillin, amoxicillin, ampicillin, sulfamethoxazole/trimethoprim (Bactrim®), tetracycline, minocycline, metronidazole (Flagyl®) and nitrofurantoin (Macrobid® or Macrodantin®) In fact, this is part of the reason why Bactrim is so widely used in young women with urinary tract infections - the fact that it typically does not interfere with contraception. I take the pill on time, as directed, every month. 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But to be on a safer side it is best to take an extra precaution for two weeks after finishing the antibiotic. I will be taking the Bactrim long-term and I am worried about it …. This medication is a combination of two antibiotics sulfamethoxazole and trimethoprim Sulfamethoxazole-TMP and Birth Control Pills Dear Dr, I have been on Apri 28-day birth control pills for over a year. All antibiotics can, at least in theory, reduce the effectiveness of oral contraceptives ("birth control") and so it is commonly recommended. ADDITIONAL CONTRACEPTION RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents Sep 05, 2016 · Antibiotics like BactrimDS can make birth control pills less effective. By lucky girl, November 26, 2008 in Prescription acne medications. It’s used to treat bacterial infections. May 16, 2017 · Annie, I took Bactrim DS for about 5 days and I am on Orsythia birth control pills. 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