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On the Depakote and had all the bad cholesterol and beginning high blood pressure that accompanies being big. Well anyways… I figured the whole drunk/high thing was a bad idea and I decided that what I …. You should not use Depakote if you have liver disease , a urea cycle disorder, low platelet counts, or a genetic disorder such as Alpers' disease or Alpers-Huttenlocher syndrome. No, it is impossible to get high off of Depakote, as all it does is repair damaged Neurotransmitters in Can You Get High Off Depakote the brain Oct 31, 2008 · I took Depakote. It is impossible to get high off of Depakote, The ER in Depakote ER means Extended Release. Im thinking that you have to get the Lamictal built up in your system first. COMMON side effects. Depakote and High blood pressure - a real-world study. 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